Best Supplements for PCOS
Polycystic ovary syndrome (PCOS) is a metabolic and hormonal condition driven primarily by insulin resistance, androgen excess, and chronic low-grade inflammation. Symptoms may include weight gain, increased facial hair, acne, and hair thinning or loss.
While lifestyle interventions are foundational, certain supplements may help support insulin sensitivity, cycle regulation, and overall metabolic balance.
Below are the supplements I most commonly recommend for individuals with PCOS, along with what they’re best suited for.
Magnesium Glycinate
Magnesium plays a role in insulin signaling and stress regulation. Many individuals with PCOS also experience elevated stress load and sleep disruption, which can further impact metabolic health.
Best for:
Sleep disruption
Insulin sensitivity support
Stress related symptoms
Avoid if:
Significant Kidney Disease
This practitioner-grade magnesium glycinate is well tolerated and appropriate for most adults seeking sleep and nervous system support.
For a detailed breakdown of the different forms of magnesium, read my guide on choosing the right type of magnesium.
Omega 3 Fatty Acids
Omega-3s help support inflammation balance and metabolic health. In PCOS, they may help reduce inflammatory signaling and support overall hormonal balance.
Best for:
Elevated triglycerides
Inflammatory symptoms
Mood support
Cardiovascular protection
Berberine
Berberine is a plant-derived compound that supports insulin sensitivity and blood sugar balance. It is sometimes compared to metformin in research settings, though it should not replace prescribed medication without medical guidance.
Best for:
Elevated fasting insulin
A1c concerns
Central weight gain
Blood sugar dysregulation
Myo-Inositol
Myo-inositol is one of the most well-studied supplements for PCOS. It helps improve insulin sensitivity and supports ovarian signaling, which may promote more regular ovulation and cycle regulation.
Best for:
Irregular cycles
Insulin resistance
Fertility and ovulation support
N-acetylcysteine (NAC)
N-acetylcysteine (NAC) supports antioxidant pathways and may help support ovulatory function in certain individuals with PCOS.
Best for:
Inflammation support
Ovulation support
Individuals not responding to first line supplements
When Supplements Aren’t Enough
PCOS management often requires a comprehensive approach including nutrition, movement, sleep, and sometimes medication. Supplements can be supportive, but they are not a replacement for individualized medical care.
NP Recommended PCOS Support Stack
For those who prefer a simplified approach, I’ve curated a practitioner-grade PCOS support stack that includes inositol, berberine, omega-3, and foundational nutrient support. Just click the button below.
Not all supplements are appropriate for everyone. If you have underlying medical conditions or take prescription medications, consult your healthcare provider before starting new supplements.
